Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP)
by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or …

Poly (ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining
genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP …

Poly (ADP-ribose) polymerase (PARP, EC 2.4. 2.30), an abundant nuclear protein activated
by DNA nicks, mediates cell death in vitro by nicotinamide adenine dinucleotide (NAD) …

Abstract Poly (ADP-ribose) polymerase (PARP)-1 is a DNA nick sensor that transforms ADP-
ribose from βNAD+ in the form of polymer to over 40 nuclear proteins, particularly to …

Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP).
Apoptosis-inducing factor (AIF) is a flavoprotein that is normally confined to the …

Background and Purpose—The nuclear enzyme poly (ADP-ribose) polymerase (PARP) may
play a role in DNA repair. However, in cerebral ischemia, excessive PARP activation may …

In the present study, the effect of poly (ADP-ribose) polymerase (PARP) inhibition on rat
cortical energy state was investigated at 24 h after global cerebral ischemia induced by …

Background and Purpose—Poly (ADP-ribose) polymerase (PARP-1; Enzyme Commission
2.4. 30) is a nuclear DNA repair enzyme that mediates early neuronal ischemic injury. Using …

The activation of poly (ADP-ribose) polymerase (PARP) in the reperfused brain after
ischemia has been assumed but never has been directly presented. Our studies indicate a …

Poly (ADP-ribose) is synthesized from nicotinamide adenine dinucleotide (NAD+) by poly
(ADP-ribose) polymerase (PARP) and degraded by poly (ADP-ribose) glycohydrolase …