Immune responses against cancer rely upon leukocyte trafficking patterns that are
coordinated by chemokines. CCR5, the receptor for chemotactic chemokines MIP1alpha …

Despite intensive study, the role of CCR5 in cancer remains elusive. We showed that CCR5
expression by both CD4+ and CD8+ T cells is necessary to boost anti-tumor responses by …

Experiments of nature have revealed the peculiar importance of the G-protein–coupled
receptor, CC chemokine receptor type 5 (CCR5), in human disease since ancient times. The …

Solid tumors are embedded in a stromal microenvironment consisting of immune cells, such
as macrophages and lymphocytes, as well as nonimmune cells, such as endothelial cells …

CC chemokine receptor type 2 (CCR2) is expressed on monocytes and facilitates their
recruitment to tumors. Though breast cancer cells also express CCR2, its functions in these …

Introduction Chemokines and their cognate receptors play a major role in modulating
inflammatory responses. Depending on their ligand binding, chemokine receptors can …

CCL4, a CC chemokine, previously known as macrophage inflammatory protein (MIP)-1β,
has diverse effects on various types of immune and nonimmune cells by the virtue of its …

CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …

The chemokine receptor CCR7 and its ligands regulate migration and colocalization of T
cells and mature dendritic cells to and within secondary lymphoid organs. The requirement …

The tumor-promoting potential of CCL5 has been proposed but remains poorly understood.
We demonstrate here that an autocrine CCL5–CCR5 axis is a major regulator of …