Differential Antibacterial Activity Against Pseudomonas aeruginosa by Carbon Monoxide-Releasing Molecules

M Desmard, R Foresti, D Morin… - Antioxidants & redox …, 2012 - liebertpub.com
Aims: Carbon monoxide (CO) delivered in a controlled manner to cells and organisms
mediates a variety of pharmacological effects to the extent that CO-releasing molecules (CO …

Ru(CO)3Cl(Glycinate) (CORM-3): A Carbon Monoxide–Releasing Molecule with Broad-Spectrum Antimicrobial and Photosensitive Activities Against Respiration and Cation …

JL Wilson, HE Jesse, B Hughes, V Lund… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: Carbon monoxide (CO) delivered to cells and tissues by CO-releasing molecules (CO-
RMs) has beneficial and toxic effects not mimicked by CO gas. The metal carbonyl Ru (CO) …

A role for reactive oxygen species in the antibacterial properties of carbon monoxide-releasing molecules

AFN Tavares, LS Nobre… - FEMS microbiology letters, 2012 - academic.oup.com
Carbon monoxide-releasing molecules (CO-RMs) are, in general, transition metal carbonyl
complexes that liberate controlled amounts of CO. In animal models, CO-RMs have been …

Reactive oxygen species mediate bactericidal killing elicited by carbon monoxide-releasing molecules

AFN Tavares, M Teixeira, CC Romão, JD Seixas… - Journal of Biological …, 2011 - ASBMB
CO-releasing molecules (CO-RMs) were previously shown by us to be more potent
bactericides than CO gas. This suggests a mechanism of action for CO-RM, which either …

Analysis of the Bacterial Response to Ru(CO)3Cl(Glycinate) (CORM-3) and the Inactivated Compound Identifies the Role Played by the Ruthenium Compound and …

S McLean, R Begg, HE Jesse, BE Mann… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Aims: Carbon monoxide (CO)-releasing molecules (CO-RMs) are being developed
with the ultimate goal of safely utilizing the therapeutic potential of CO clinically. One such …

A carbon monoxide‐releasing molecule (CORM‐3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of …

M Desmard, KS Davidge, O Bouvet, D Morin… - The FASEB …, 2009 - Wiley Online Library
The search for new molecules to fight Pseudomonas aeruginosa is of paramount
importance. Carbon monoxide (CO) is known to act as an effective inhibitor of the respiratory …

[HTML][HTML] A thiol-reactive Ru (II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

HM Southam, TW Smith, RL Lyon, C Liao, CR Trevitt… - Redox biology, 2018 - Elsevier
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds,
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …

'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects

HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …

Recent advances on carbon monoxide releasing molecules for antibacterial applications

J Cheng, J Hu - ChemMedChem, 2021 - Wiley Online Library
Carbon monoxide (CO) has been known as an endogenous signaling molecule in addition
to an air pollutant. It plays a critical role in many physiological and pathological processes …

Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators

KS Davidge, G Sanguinetti, CH Yee, AG Cox… - Journal of Biological …, 2009 - ASBMB
Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, anti-
inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value …