If the new environment and modern lifestyle cause obesity in individuals with thrifty genes by
increasing energy intake, it is important to know by what mechanisms hyperphagia occurs …

Highlights•Discrete neuronal populations are sufficient for driving appetite and
satiety.•These neurons are regulated by sensory, hormonal, and exogenous …

Hunger, mostly initiated by a deficiency in energy, induces food seeking and intake.
However, the drive toward food is not only regulated by physiological needs, but is …

Obesity is a growing public health problem. Although convenient, the notion that obesity is
simply a problem of will power is increasingly antiquated. It is becoming clear that complex …

The obesity epidemic in the US and abroad has increased interest in neurobiological
mechanisms that contribute to eating in the absence of energy demand or hunger …

In a restrictive food environment, the homeostatic control system regulates body weight and
adiposity with remarkable precision. However, this regulation appears to break down in …

A neural network sensitive to leptin and other energy status signals stretching from the
hypothalamus to the caudal medulla has been identified as the homeostatic control system …

Appetite and body weight regulation are controlled by the central nervous system (CNS) in a
rather complicated manner. The human brain plays a central role in integrating internal and …

Interest in the control of feeding has increased as a result of the obesity epidemic and rising
incidence of metabolic diseases. The brain detects alterations in energy stores and triggers …

According to the World Health OrganizationLs report, approximately 13% of the worldLs
adult population was obese, and 39% was overweight in 2016. The worldwide prevalence of …