Background Intestinal nutrient sensing regulates food intake and energy metabolism by
acting locally and relaying nutritional status to the brain. It is unclear whether these …

Background Activation of the ileal brake through the delivery of nutrients into the distal small
intestine to promote satiety and suppress food intake provides a new target for weight loss …

BACKGROUND & AIMS: The gut-brain axis, which transmits nutrient information from the
gastrointestinal tract to the brain, is important for the detection of dietary nutrients. We used …

For the past several decades, vagal and hormonal gut–brain negative feedback signaling
mechanisms that promote satiety and subsequent suppression of food intake have been …

Background: The interaction of nutrients with the small intestine modulates
gastropyloroduodenal motility, stimulates the release of gut hormones, and suppresses …

We previously showed that hypothalamic neuronal activity, as measured by the blood
oxygen level-dependent (BOLD) functional MRI signal, declines in response to oral glucose …

Background Rapid gastric balloon distension to discomfort threshold activates the “pain
neuromatrix” and deactivates exteroceptive sensory and “default mode network” regions …

The ability to “see” both incoming and circulating nutrients plays an essential role in the
maintenance of energy homeostasis. As such, nutrient-sensing mechanisms in both the …

Background: Jejunal feeding is preferred instead of gastric feeding in patients who are
intolerant to gastric feeding or at risk of aspiration. However, the impact of gastric feeding …

We have previously identified pyloric pressures and plasma cholecystokinin (CCK)
concentrations as independent determinants of energy intake following administration of …