Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation
P Zhang, B Lu, R Zhu, D Yang, W Liu… - Journal of …, 2021 - Wiley Online Library
Abstract Background and Objective Diabetes accelerates inflammaging in various tissue
with an increase in senescent cell burden and senescence‐associated secretory phenotype …
with an increase in senescent cell burden and senescence‐associated secretory phenotype …
[HTML][HTML] Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation
Inflamm-aging was recently affiliated with the progression of diabetic complications. Local
cellular senescence together with senescence-associated secretory phenotype (SASP) are …
cellular senescence together with senescence-associated secretory phenotype (SASP) are …
[HTML][HTML] Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging
Hyperglycemia induces chronic low-grade inflammation (inflammaging), which is a newly
identified contributor to diabetes-related tissue lesions, including the inflammatory bone loss …
identified contributor to diabetes-related tissue lesions, including the inflammatory bone loss …
[HTML][HTML] Hyperglycemia aggravates periodontitis via autophagy impairment and ROS-inflammasome-mediated macrophage pyroptosis
Z Zhao, Y Ming, X Li, H Tan, X He, L Yang… - International journal of …, 2023 - mdpi.com
Macrophage pyroptosis drives the secretion of IL-1β, which has been recently reported to be
a featured salivary biomarker for discriminating periodontitis in the presence of diabetes …
a featured salivary biomarker for discriminating periodontitis in the presence of diabetes …
Hyperglucose contributes to periodontitis: involvement of the NLRP3 pathway by engaging the innate immunity of oral gingival epithelium
X Huang, X Yang, J Ni, B Xie, Y Liu… - Journal of …, 2015 - Wiley Online Library
Background: The NLRP3 inflammasome is essentially a family of intracellular innate
immune sensors that can respond to bacterial challenge and initiate early host immunity …
immune sensors that can respond to bacterial challenge and initiate early host immunity …
Metformin ameliorates the NLPP3 inflammasome mediated pyroptosis by inhibiting the expression of NEK7 in diabetic periodontitis
Objectives To investigate the underlying mechanism between diabetic periodontitis and
NLR family pyrin domain containing 3 (NLRP3) inflammasome associated pyroptosis …
NLR family pyrin domain containing 3 (NLRP3) inflammasome associated pyroptosis …
Hyperglycaemia‐associated macrophage pyroptosis accelerates periodontal inflamm‐aging
Aim Pyroptosis and inflamm‐aging have been newly identified to be involved in diabetic
periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in …
periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in …
High glucose‐induced oxidative stress increases IL‐8 production in human gingival epithelial cells
Y Kashiwagi, M Takedachi, K Mori, M Kubota… - Oral …, 2016 - Wiley Online Library
Objective Diabetes is often associated with increased prevalence and severity of periodontal
disease. We hypothesized that gingival epithelial cells modify periodontal disease …
disease. We hypothesized that gingival epithelial cells modify periodontal disease …
[HTML][HTML] Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts
CY Huang, MY Ng, T Lin, YW Liao, WS Huang… - Journal of Dental …, 2024 - Elsevier
Background/purpose Diabetes mellitus (DM) and periodontal disease are both prevalent
and chronic inflammatory disorders that have significant health impact. Many studies have …
and chronic inflammatory disorders that have significant health impact. Many studies have …
Advanced glycation end‐products increase IL‐6 and ICAM‐1 expression via RAGE, MAPK and NF‐κB pathways in human gingival fibroblasts
K Nonaka, Y Kajiura, M Bando… - Journal of …, 2018 - Wiley Online Library
Background and Objectives Diabetes mellitus (DM) is a risk factor for periodontal diseases
and may exacerbate the progression of the pathogenesis of periodontitis. Advanced …
and may exacerbate the progression of the pathogenesis of periodontitis. Advanced …