Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation

P Zhang, B Lu, R Zhu, D Yang, W Liu… - Journal of …, 2021 - Wiley Online Library
Abstract Background and Objective Diabetes accelerates inflammaging in various tissue
with an increase in senescent cell burden and senescence‐associated secretory phenotype …

[HTML][HTML] Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation

P Zhang, Q Wang, L Nie, R Zhu, X Zhou, P Zhao… - Journal of Biological …, 2019 - ASBMB
Inflamm-aging was recently affiliated with the progression of diabetic complications. Local
cellular senescence together with senescence-associated secretory phenotype (SASP) are …

[HTML][HTML] Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging

Q Wang, L Nie, P Zhao, X Zhou, Y Ding… - International journal of …, 2021 - nature.com
Hyperglycemia induces chronic low-grade inflammation (inflammaging), which is a newly
identified contributor to diabetes-related tissue lesions, including the inflammatory bone loss …

[HTML][HTML] Hyperglycemia aggravates periodontitis via autophagy impairment and ROS-inflammasome-mediated macrophage pyroptosis

Z Zhao, Y Ming, X Li, H Tan, X He, L Yang… - International journal of …, 2023 - mdpi.com
Macrophage pyroptosis drives the secretion of IL-1β, which has been recently reported to be
a featured salivary biomarker for discriminating periodontitis in the presence of diabetes …

Hyperglucose contributes to periodontitis: involvement of the NLRP3 pathway by engaging the innate immunity of oral gingival epithelium

X Huang, X Yang, J Ni, B Xie, Y Liu… - Journal of …, 2015 - Wiley Online Library
Background: The NLRP3 inflammasome is essentially a family of intracellular innate
immune sensors that can respond to bacterial challenge and initiate early host immunity …

Metformin ameliorates the NLPP3 inflammasome mediated pyroptosis by inhibiting the expression of NEK7 in diabetic periodontitis

X Zhou, Q Wang, L Nie, P Zhang, P Zhao, Q Yuan… - Archives of oral …, 2020 - Elsevier
Objectives To investigate the underlying mechanism between diabetic periodontitis and
NLR family pyrin domain containing 3 (NLRP3) inflammasome associated pyroptosis …

Hyperglycaemia‐associated macrophage pyroptosis accelerates periodontal inflamm‐aging

P Zhao, Z Yue, L Nie, Z Zhao, Q Wang… - Journal of Clinical …, 2021 - Wiley Online Library
Aim Pyroptosis and inflamm‐aging have been newly identified to be involved in diabetic
periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in …

High glucose‐induced oxidative stress increases IL‐8 production in human gingival epithelial cells

Y Kashiwagi, M Takedachi, K Mori, M Kubota… - Oral …, 2016 - Wiley Online Library
Objective Diabetes is often associated with increased prevalence and severity of periodontal
disease. We hypothesized that gingival epithelial cells modify periodontal disease …

[HTML][HTML] Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts

CY Huang, MY Ng, T Lin, YW Liao, WS Huang… - Journal of Dental …, 2024 - Elsevier
Background/purpose Diabetes mellitus (DM) and periodontal disease are both prevalent
and chronic inflammatory disorders that have significant health impact. Many studies have …

Advanced glycation end‐products increase IL‐6 and ICAM‐1 expression via RAGE, MAPK and NF‐κB pathways in human gingival fibroblasts

K Nonaka, Y Kajiura, M Bando… - Journal of …, 2018 - Wiley Online Library
Background and Objectives Diabetes mellitus (DM) is a risk factor for periodontal diseases
and may exacerbate the progression of the pathogenesis of periodontitis. Advanced …