MicroRNA-21 (miR-21) plays a significant role in the regulation of fibrotic and inflammatory
gene expression signatures. Endogenous miR-21 shows robust expression in different types …

Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as a
key factor in the development of heart failure, but the mechanisms undelying cardiac fibrosis …

Myocardial ischaemia is a condition in which the coronary blood flow to the heart is reduced,
which results in deficient oxygen and nutrients supply to the heart. In the clinical setting …

Rationale Myocardial infarction (MI) triggers a dynamic microRNA response with the
potential of yielding therapeutic targets. Objective We aimed to identify novel aberrantly …

MicroRNAs (miRNAs) control the expression of diverse subsets of target mRNAs, and
studies have found miRNA dysregulation in failing hearts. Expression of miR-29 is abundant …

Background miR-21 is a central regulator of cardiac fibrosis, and its inhibition in small-
animal models has been shown to be an effective antifibrotic strategy in various organs …

We read Wang's Review [1] with great interest and would like to discuss some novel
microRNAs (miRs) involved in regulation of cardiac fibrosis which not mentioned in this …

Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the
development of heart failure. Although dysregulation of microRNA (miRNA) is involved in …

MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology,
and we previously reported that inhibition of miR-34a in vivo provided protection in a setting …

miR-21 is a 22-nucleotide long microRNA that matches target mRNAs in a complementary
base pairing fashion and regulates gene expression by repressing or degrading target …