Platforms for investigating LncRNA functions

JL Charles Richard… - … : Translating Life Sciences …, 2018 - journals.sagepub.com
Prior to the sequencing of the human genome, it was presumed that most of the DNA coded
for proteins. However, with the advent of next-generation sequencing, it has now been …

Technological developments in lncRNA biology

S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …

Linking RNA biology to lncRNAs

LA Goff, JL Rinn - Genome research, 2015 - genome.cshlp.org
The regulatory potential of RNA has never ceased to amaze: from RNA catalysis, to RNA-
mediated splicing, to RNA-based silencing of an entire chromosome during dosage …

[HTML][HTML] Exploring long non-coding RNAs through sequencing

SR Atkinson, S Marguerat, J Bähler - Seminars in cell & developmental …, 2012 - Elsevier
Long non-coding RNAs (lncRNAs) are emerging as an important class of regulatory
transcripts that are implicated in a variety of biological functions. RNA-sequencing, along …

Modulating the expression of long non‐coding RNA s for functional studies

SJ Liu, DA Lim - EMBO reports, 2018 - embopress.org
Long non‐coding RNA s (lnc RNA s) have emerged as important regulators of cell biology.
The mechanisms by which lnc RNA s function are likely numerous, and most are poorly …

The lncRNA toolkit: databases and in silico tools for lncRNA analysis

HR Pinkney, BM Wright, SD Diermeier - Non-coding RNA, 2020 - mdpi.com
Long non-coding RNAs (lncRNAs) are a rapidly expanding field of research, with many new
transcripts identified each year. However, only a small subset of lncRNAs has been …

The specificity of long noncoding RNA expression

BS Gloss, ME Dinger - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Over the last decade, long noncoding RNAs (lncRNAs) have emerged as a fundamental
molecular class whose members play pivotal roles in the regulation of the genome. The …

[HTML][HTML] Genome-wide methods for investigating long noncoding RNAs

M Cao, J Zhao, G Hu - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Long noncoding RNAs (lncRNAs) are large RNA transcripts that do not code for proteins but
exert their effects in the form of RNA. To date many thousands of lncRNAs have been …

Functional analysis of long noncoding RNAs in development and disease

LL Chen, JC Zhao - Systems Biology of RNA Binding Proteins, 2014 - Springer
Once viewed as part of the “dark matter” of genome, long noncoding RNAs (lncRNAs), which
are mRNA-like but lack open reading frames, have emerged as an integral part of the …

[PDF][PDF] Molecular mechanisms of long noncoding RNAs

KC Wang, HY Chang - Molecular cell, 2011 - cell.com
Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a
variety of biological functions. Here we discuss the emerging archetypes of molecular …