Tumor spheroids are increasingly recognized as an important in vitro model for the behavior
of tumor cells in three dimensions. More physiologically relevant than conventional adherent …

Summary Three-dimensional (3D) cancer cell culture models such as tumor spheroids better
recapitulate in vivo tumors than conventional two-dimensional models. However, two major …

Tumor spheroids are three-dimensional clusters of cancer cells that exhibit characteristics of
poorly perfused tumors and hence present a relevant model for testing the efficacy of anti …

Cancer cells have routinely been cultured in two dimensions (2D) on a plastic surface. This
technique, however, lacks the true environment a tumor mass is exposed to in vivo. Solid …

Multicellular tumor spheroids are rapidly emerging as an improved in vitro model with
respect to more traditional 2D culturing. Microwell culturing is a simple and accessible …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Multicellular tumor spheroids are attracting more attention as a physiologically relevant in
vitro tumor model for biomedical research. The size of spheroids is one of the critical …

Spheroids are widely used in biology because they provide an in vitro 3-dimensional (3D)
model to study proliferation, cell death, differentiation, and metabolism of cells in tumors and …

Tumor models that closely imitate in vivo conditions are becoming increasingly popular in
drug discovery and development for the screening of potential anti-cancer drugs …

Spheroids are recognized for replicating the physiological microenvironment of tumours.
However, because of the lack of controllability of the spheroid size, the response to …