Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …

The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as
one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell …

Loss-of-function mutations in KMT2D are a striking feature of germinal center (GC)
lymphomas, resulting in decreased histone 3 lysine 4 (H3K4) methylation and altered gene …

Cancer cells adapt their metabolic activities to support growth and proliferation. However,
increased activity of metabolic enzymes is not usually considered an initiating event in the …

Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which
contribute to it as a recalcitrant malignancy. To understand the molecular mechanisms …

Abstract KMT2D (lysine (K)-specific methyltransferase 2D), formerly named MLL2
(myeloid/lymphoid or mixed-lineage leukemia 2, also known as ALR/MLL4), is a histone …

Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …

Germinal center (GC) B cells feature repression of many gene enhancers to establish their
characteristic transcriptome. Here we show that conditional deletion of Lsd1 in GCs …

Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

The KMT2 (lysine methyltransferase) family of histone modifying proteins play essential
roles in regulating developmental pathways, and mutations in the genes encoding these …