Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …

Significance: Synaptic degeneration, an early pathological feature in Alzheimer's disease
(AD), is closely correlated to impaired cognitive function and memory loss. Recent studies …

Significance: Alzheimer's disease (AD) is an age-related progressive neurodegenerative
disorder mainly affecting elderly individuals. The pathology of AD is characterized by …

Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau
neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early …

Growing evidence suggests that amyloid beta (Aβ) and tau pathologies are strongly
associated with mitochondrial dysfunction and neuronal damage in Alzheimer's disease …

Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

Alzheimer's disease (AD) is a progressive and synaptic failure disease. Despite the many
years of research, AD still harbors many secrets. As more of the world's population grows …

Our latest publication on the inhibition of Alzheimer disease (AD) through mitophagy
consolidates the 'defective mitophagy hypothesis of AD etiology'. Dementia (majorly AD) …

Amyloid-β has long been implicated in the pathogenesis of Alzheimer disease. The focus
was initially on the extracellular fibrillar deposits of amyloid-β but more recently has shifted …