Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy.
We previously demonstrated retinal repair and restoration of vision through transplantation …

Retinal degenerative diseases resulting in the loss of photoreceptors are one of the major
causes of blindness. Photoreceptor replacement therapy is a promising treatment because …

Loss of photoreceptors due to retinal degeneration is a major cause of untreatable
blindness. Cell replacement therapy, using pluripotent stem cell-derived photoreceptor cells …

Retinitis pigmentosa, other inherited retinal diseases, and age-related macular
degeneration lead to untreatable blindness because of the loss of photoreceptors. We have …

Retinal degeneration is a leading cause of irreversible blindness in the developed world.
Differentiation of retinal cells, including photoreceptors, from both mouse and human …

One strategy to restore vision in retinitis pigmentosa and age-related macular degeneration
is cell replacement. Typically, patients lose vision when the outer retinal photoreceptor layer …

Cell transplantation is a novel therapeutic strategy to restore visual responses to the
degenerate adult neural retina and represents an exciting area of regenerative …

We previously reported the differentiation of mouse embryonic stem (ES) cells into retinal
progenitors. However, these progenitors rarely differentiate into photoreceptors unless they …

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …

Retinal transplantation therapy for retinitis pigmentosa is increasingly of interest due to
accumulating evidence of transplantation efficacy from animal studies and development of …