Objectives–We study the power of IgG synthesis value as a marker of disease activity in
multiple sclerosis (MS). Material and methods–Link index was calculated in 202 MS …

Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple
sclerosis (MS). The aim of this study was the follow‐up of a group of relapsing‐remitting MS …

An empirical formula has been developed to calculate the de novo rate of synthesis of IgG in
the central nervous system (CNS), based on physiologic principles that govern the passage …

The intrathecal synthesis of IgM, determined at clinical onset in patients with multiple
sclerosis, was found to correlate with the degree of disability (as evaluated by means of the …

Intrathecal IgM synthesis was assessed through the detection of oligoclonal bands in
cerebrospinal fluid (CSF) and through calculation of IgM index values and total CSF IgM …

Background: There is emerging evidence that intrathecal IgM synthesis (ITMS) is a risk factor
for conversion to clinically defined multiple sclerosis (CDMS) in clinically isolated syndrome …

Objective We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal
synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting …

There are several formulas for the quantitative determination of intrathecal IgG production:
Reiber and Felgenhauer's formula (IgG (loc)), the Extended IgG index, Tourtellotte's formula …

Importance Reliable biomarkers associated with disability worsening in multiple sclerosis
(MS) are still needed. Objective To determine a possible association of intrathecal IgG …

Isoelectric focusing of CSF and serum IgG followed by crossed immuno isoelectric focusing
and direct immunofixation as well as quantitative assay of IgG and albumin were performed …