Epidermal Growth Factor Receptor and Transforming Growth Factor β Signaling Pathways Cooperate To Mediate Chlamydia Pathogenesis

JU Igietseme, J Partin, Z George, Y Omosun… - Infection and …, 2020 - Am Soc Microbiol
Human genital Chlamydia infection is a major public health concern due to the serious
reproductive system complications. Chlamydia binds several receptor tyrosine kinases …

Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development

AL Patel, X Chen, ST Wood, ES Stuart, KF Arcaro… - BMC microbiology, 2014 - Springer
Background Chlamydia trachomatis (C. trachomatis) is a clinically significant human
pathogen and one of the leading causative agents of sexually transmitted diseases. As …

Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis

JU Igietseme, Y Omosun, O Stuchlik, MS Reed… - PloS one, 2015 - journals.plos.org
Chlamydia trachomatis genital infection in women causes serious adverse reproductive
complications, and is a strong co-factor for human papilloma virus (HPV)-associated cervical …

Molecular pathogenesis of chlamydia disease complications: epithelial-mesenchymal transition and fibrosis

JU Igietseme, Y Omosun, T Nagy, O Stuchlik… - Infection and …, 2018 - Am Soc Microbiol
The reproductive system complications of genital chlamydial infection include fallopian tube
fibrosis and tubal factor infertility. However, the molecular pathogenesis of these …

Insights Into Host Cell Cytokines in Chlamydia Infection

W Xiang, N Yu, A Lei, X Li, S Tan, L Huang… - Frontiers in …, 2021 - frontiersin.org
Chlamydial infection causes a number of clinically relevant diseases and induces significant
morbidity in humans. Immune and inflammatory responses contribute to both the clearance …

The dual role of cytokine responses to Chlamydia trachomatis infection in host pathogen crosstalk

S Min, P He, Q Zhou, H Chen - Microbial pathogenesis, 2022 - Elsevier
Chlamydia-induced diseases are a significant human health disease. In recent years, a
large number of studies have helped to gradually improve our understanding of chlamydia …

New insights in Chlamydia: host interactions and pathogenesis

HA Saka, MT Damiani - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Chlamydia are ancient and successful pathogens, evolutionary distinct from most bacteria
and highly adapted to an intracellular lifestyle. To propagate, Chlamydia deploy a plethora …

Immunopathogenesis of chlamydial infections

AK Murthy, W Li, KH Ramsey - Biology of Chlamydia, 2018 - Springer
Chlamydial infections lead to a number of clinically relevant diseases and induce significant
morbidity in human populations. It is generally understood that certain components of the …

Chlamydia trachomatis Serovars Drive Differential Production of Proinflammatory Cytokines and Chemokines Depending on the Type of Cell Infected

R Faris, SE Andersen, A McCullough… - Frontiers in cellular …, 2019 - frontiersin.org
Chlamydia trachomatis serovars AC infect conjunctival epithelial cells and untreated
infection can lead to blindness. DK infect genital tract epithelial cells resulting in pelvic …

Is There a Hidden Burden of Disease as a Result of Epigenetic Epithelial-to-Mesenchymal Transition Following Chlamydia trachomatis Genital Tract Infection?

PJ Horner, H Flanagan, AW Horne - The Journal of Infectious …, 2021 - academic.oup.com
Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection
worldwide, has been widely researched for its involvement in many disease pathologies in …