The placenta participates in maternal insulin sensitivity changes during pregnancy;
however, mechanisms remain unclear. We investigated associations between maternal …

Maternal hyperglycemia during pregnancy is associated with excess fetal growth and
adverse perinatal and developmental outcomes. Placental epigenetic maladaptation may …

Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …

Background In utero exposure to diabetes has been shown to contribute to preterm birth,
though the underlying biological mechanisms are yet to be fully elucidated. Fetal epigenetic …

Background Studies have shown that the effects of maternal nutrition exposure during
gestation influence metabolic risk in early life through an epigenetic mechanism. Low …

Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …

Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …

Background Fetal exposure to maternal GDM increases offspring risk for adult-onset
metabolic syndromes. Epigenetic modifications such as DNA methylation are modulators for …

Several recent reports have described associations between gestational diabetes (GDM)
and changes to the epigenomic landscape where the DNA samples were derived from …

OBJECTIVE Maternal glycemic dysregulation during pregnancy increases the risk of
adverse health outcomes in her offspring, a risk thought to be linearly related to maternal …