With the awareness that immune-inflammatory cross-talk is at the heart of many disorders,
the desire for novel immunomodulatory strategies in the therapy of such diseases has grown …

The complement system is an essential component of innate immunity that has been more
recently recognized as an unexpected player in various pathological states. These include …

Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …

Ocular inflammation is a defining feature of sight threating diseases and its dysregulation
can catalyze and or propagate ocular neurodegenerative maladies such as age-related …

The complement system is a powerful effector arm of innate immunity that typically confers
protection from microbial intruders and accumulating debris. In many clinical situations …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

In addition to its essential role in immune defense, the complement system contributes to
tissue damage in many clinical conditions. Thus, there is a pressing need to develop …

The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …

The complement system is an important part of the innate and adaptive immune systems.
Originally characterized as a single serum component contributing to the killing of bacteria …

The complement system is best known for its role in innate immunity, providing a first line of
defence against infection, maintaining tissue homeostasis by flagging apoptotic cells and …