Objective—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …

Mitochondrial reactive oxygen species (mtROS) are signaling molecules, which drive
inflammatory cytokine production and T cell activation. In addition, cardiovascular diseases …

Rationale: Mitochondrial oxidative stress (mitoOS) has been shown to correlate with the
progression of human atherosclerosis. However, definitive cell type–specific causation …

Mitochondria are well known for their central roles in ATP production, calcium homeostasis,
and heme and steroid biosynthesis. However, mitochondrial reactive oxygen species (ROS) …

Functional and structural changes in mitochondria are caused by the opening of the
mitochondrial permeability transition pore (PTP) and by the mitochondrial generation of …

Mitochondrial-derived reactive oxygen species (mtROS) is one of the major sources of
cellular ROS, and excessive mtROS is associated with atherosclerosis progression in both …

Lysophosphatidylcholine (lysoPC) evokes diverse biological responses in vascular cells
including Ca2+ mobilization, production of reactive oxygen species, and activation of the …

High levels of reactive oxygen species (ROS) are observed in chronic human diseases such
as obesity, type 2 diabetes, atherosclerosis, and cardiovascular diseases. In addition to the …

Mitochondria have long been known to play a critical role in maintaining the bioenergetic
status of cells under physiological conditions. It was also recognized early in mitochondrial …

Mitochondria are capable of detecting cellular insults and orchestrating inflammatory
responses. Mitochondrial reactive oxygen species (mtROS) are intermediates that trigger …