Stress management at the ER: regulators of ER stress-induced apoptosis
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function
and survival. Conditions that interfere with ER function lead to the accumulation and …
and survival. Conditions that interfere with ER function lead to the accumulation and …
[HTML][HTML] ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”
F Walter, A O'Brien, CG Concannon… - Journal of Biological …, 2018 - ASBMB
In response to an accumulation of unfolded proteins in the endoplasmic reticulum (ER)
lumen, three ER transmembrane signaling proteins, inositol-requiring enzyme 1 (IRE1) …
lumen, three ER transmembrane signaling proteins, inositol-requiring enzyme 1 (IRE1) …
[HTML][HTML] Signaling pathways from the endoplasmic reticulum and their roles in disease
H Kadowaki, H Nishitoh - Genes, 2013 - mdpi.com
The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and
transmembrane proteins are assembled and folded into their correct tertiary structures …
transmembrane proteins are assembled and folded into their correct tertiary structures …
Endoplasmic reticulum stress responses
M Schröder - Cellular and molecular life sciences, 2008 - Springer
In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of
homeostasis causes stress. In this review I summarize how perturbation of three major …
homeostasis causes stress. In this review I summarize how perturbation of three major …
IRE1 signaling affects cell fate during the unfolded protein response
JH Lin, H Li, D Yasumura, HR Cohen, C Zhang… - science, 2007 - science.org
Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed
the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) …
the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) …
Stressed to death–mechanisms of ER stress-induced cell death
The endoplasmic reticulum (ER) is a highly dynamic organelle of fundamental importance
present in all eukaryotic cells. The majority of synthesized structural and secreted proteins …
present in all eukaryotic cells. The majority of synthesized structural and secreted proteins …
Role of the unfolded protein response in organ physiology: lessons from mouse models
The endoplasmic reticulum (ER) is a key subcellular compartment involved in the folding
and maturation of around one‐third of the total proteome. Accumulation of misfolded …
and maturation of around one‐third of the total proteome. Accumulation of misfolded …
Endoplasmic reticulum stress signalling–from basic mechanisms to clinical applications
A Almanza, A Carlesso, C Chintha… - The FEBS …, 2019 - Wiley Online Library
The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …
compartment of the secretory pathway. As such, the ER contributes to the production and …
[HTML][HTML] Multiple mechanisms of unfolded protein response–induced cell death
N Hiramatsu, WC Chiang, TD Kurt, CJ Sigurdson… - The American journal of …, 2015 - Elsevier
Eukaryotic cells fold and assemble membrane and secreted proteins in the endoplasmic
reticulum (ER), before delivery to other cellular compartments or the extracellular …
reticulum (ER), before delivery to other cellular compartments or the extracellular …
How transmembrane proteins sense endoplasmic reticulum stress
K Kohno - Antioxidants & redox signaling, 2007 - liebertpub.com
The unfolded protein response (UPR) is an adaptive stress response in which cells recover
from the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) …
from the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) …