Within the cell, several mechanisms exist to maintain homeostasis of the endoplasmic
reticulum (ER). One of the primary mechanisms is the unfolded protein response (UPR). In …

The unfolded protein response (UPR) is a collection of intracellular pathways that function to
maintain homeostasis in the ER. The mammalian UPR is distinguished by three ER-resident …

Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when
protein folding demand overcomes the folding capacity of this compartment, thereby leading …

Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling
pathways, collectively termed the Unfolded Protein Response (UPR). UPR signaling …

Endoplasmic reticulum (ER) stress is a common feature of several physiological and
pathological conditions affecting the function of the secretory pathway. To restore ER …

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane
proteins are synthesized and folded. Correctly folded proteins exit the ER and are …

The endoplasmic reticulum (ER) is recognized primarily as the site of synthesis and folding
of secreted and membrane‐bound proteins. The ER provides stringent quality control …

The kinases PERK and IRE1 alleviate endoplasmic reticulum (ER) stress by orchestrating
the unfolded protein response (UPR). If stress mitigation fails, PERK promotes cell death by …

This chapter provides an overview of our present understanding of mechanisms of sensing
protein folding status and endoplasmic reticulum (ER) stress in eukaryotic cells. The ER …

Increased demand on the protein folding capacity of the endoplasmic reticulum (ER)
engages an adaptive reaction known as the unfolded protein response (UPR). The UPR …