Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
I Kim, W Xu, JC Reed - Nature reviews Drug discovery, 2008 - nature.com
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …
cellular stress induced by multiple stimuli and pathological conditions. These include …
The unfolded protein response: from stress pathway to homeostatic regulation
The vast majority of proteins that a cell secretes or displays on its surface first enter the
endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled …
endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled …
Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update
The endoplasmic reticulum (ER)-induced unfolded protein response (UPR) is an adaptive
mechanism that is activated upon accumulation of misfolded proteins in the ER and aims at …
mechanism that is activated upon accumulation of misfolded proteins in the ER and aims at …
Mechanisms, regulation and functions of the unfolded protein response
C Hetz, K Zhang, RJ Kaufman - Nature reviews Molecular cell biology, 2020 - nature.com
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
That which does not kill me makes me stronger: adapting to chronic ER stress
DT Rutkowski, RJ Kaufman - Trends in biochemical sciences, 2007 - cell.com
Cells respond to the accumulation of unfolded proteins by activating signal transduction
cascades that improve protein folding. One example of such a cascade is the unfolded …
cascades that improve protein folding. One example of such a cascade is the unfolded …
Role of the unfolded protein response in cell death
R Kim, M Emi, K Tanabe, S Murakami - Apoptosis, 2006 - Springer
Unfolded protein response (UPR) is an important genomic response to endoplasmic
reticulum (ER) stress. The ER chaperones, GRP78 and Gadd153, play critical roles in cell …
reticulum (ER) stress. The ER chaperones, GRP78 and Gadd153, play critical roles in cell …
Measuring ER stress and the unfolded protein response using mammalian tissue culture system
CM Oslowski, F Urano - Methods in enzymology, 2011 - Elsevier
The endoplasmic reticulum (ER) functions to properly fold and process secreted and
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause …
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause …
Endoplasmic reticulum stress response in yeast and humans
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms
in response to stress. One of the best-characterized pathways, the UPR (unfolded protein …
in response to stress. One of the best-characterized pathways, the UPR (unfolded protein …
Getting the better of ER stress
B Mollereau, S Manié, F Napoletano - Journal of cell communication and …, 2014 - Springer
Research over the past few years has highlighted the ability of the unfolded protein
response (UPR) to minimize the deleterious effects of accumulated misfolded proteins under …
response (UPR) to minimize the deleterious effects of accumulated misfolded proteins under …
Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress
JB DuRose, AB Tam, M Niwa - Molecular biology of the cell, 2006 - Am Soc Cell Biol
The unfolded protein response (UPR) regulates the protein-folding capacity of the
endoplasmic reticulum (ER) according to cellular demand. In mammalian cells, three ER …
endoplasmic reticulum (ER) according to cellular demand. In mammalian cells, three ER …