Simple Summary The unfolded protein response (UPR) is the cells' way of maintaining the
balance of protein folding in the endoplasmic reticulum, which is the section of the cell …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

The ability of translated cellular proteins to perform their functions requires their proper
folding after synthesis. The endoplasmic reticulum (ER) is responsible for coordinating …

Endoplasmic reticulum (ER) protein misfolding activates the unfolded protein response
(UPR) to help cells cope with ER stress. If ER homeostasis is not restored, UPR promotes …

Eukaryotic cells can adapt to endoplasmic reticulum (ER) dysfunction by producing diverse
signals from the ER to the cytosol or nucleus. These signalling pathways are collectively …

The endoplasmic reticulum (ER) is the first compartment of secretory pathway. It plays a
major role in ER chaperone-assisted folding and quality control, including post-translational …

Besides protein processing, the endoplasmic reticulum (ER) has several other functions
such as lipid synthesis, the transfer of molecules to other cellular compartments, and the …

Secretory and transmembrane proteins enter the endoplasmic reticulum (ER) as unfolded
proteins and exit as either folded proteins in transit to their target organelles or as misfolded …

The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER),
due to genetic determinants and extrinsic environmental factors, leads to endoplasmic …

Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …