The specificity and efficiency of tumor‐cell lysis by the retargeting of murine cytolytic
lymphocytes (CTL) with bispecific antibodies was examined. Bispecific antibodies (also …

The specificity and efficiency of tumor cell lysis by the retargeting of murine and human
cytolytic T lymphocytes (CTL) with heteroaggregated (also known as bispecific or hybrid) …

Antibodies to the clonally unique variable-region determinants (idiotype) of the antigen-
specific alpha beta heterodimeric receptor of a clone of cytotoxic T cells (CTLs) were shown …

Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell
fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill …

Heteroaggregates containing anti-T3 cross-linked to anti-target cell antibodies have been
shown to cause human T cells to lyse target cells that express antigens recognized by the …

Linking an antitumor cell antibody with an antilymphocyte antibody produces a bifunctional
antibody that can redirect T lymphocytes to lyse tumor cells. Bifunctional antibodies that …

Covalent linkage of an antitumour antibody specific for a tumour cell surface antigen to an
antilymphocyte antibody specific for the T lymphocyte receptor complex produces a …

We have previously described the generation of bispecific anti-TCR* anti-tumor mAb,
intended for in vivo analysis of T cell retargeting in a syngeneic rat colon carcinoma model …

Two different bispecific hybrid antibodies were generated by cell fusion of pairs of existing
hybrid-myeloma cell lines. Both hybrid antibodies had similar specificity for human CD3 and …

T cells can be induced to specifically lyse tumor cells with bispecific antibodies containing
anti-T cell receptor mAbs crosslinked to anti-tumor mAbs. Such «targeted cytolysis» requires …