Patterns of drug release as a function of drug loading from amorphous solid dispersions: A comparison of five different polymers.
To reduce the pill burden associated with amorphous solid dispersions (ASDs), which arises
from the large quantity of polymer used in the formulation, it is of interest to understand the …
from the large quantity of polymer used in the formulation, it is of interest to understand the …
Initial drug dissolution from amorphous solid dispersions controlled by polymer dissolution and drug-polymer interaction
Y Chen, S Wang, S Wang, C Liu, C Su… - Pharmaceutical …, 2016 - Springer
Purpose To identify the key formulation factors controlling the initial drug and polymer
dissolution rates from an amorphous solid dispersion (ASD). Methods Ketoconazole (KTZ) …
dissolution rates from an amorphous solid dispersion (ASD). Methods Ketoconazole (KTZ) …
Congruent release of drug and polymer: A “sweet spot” in the dissolution of amorphous solid dispersions
Liquid-liquid phase separation (LLPS) occurs following amorphous solid dispersion (ASD)
dissolution when the drug concentration exceeds the “amorphous solubility”, and is …
dissolution when the drug concentration exceeds the “amorphous solubility”, and is …
Dissolution mechanisms of amorphous solid dispersions: role of drug load and molecular interactions
High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate
partially because drug release is inhibited at high drug loads. The maximum drug load prior …
partially because drug release is inhibited at high drug loads. The maximum drug load prior …
Impact of polymer type, ASD loading and polymer-drug ratio on ASD tablet disintegration and drug release
Amorphous solid dispersion (ASD) has become an attractive strategy to enhance solubility
and bioavailability of poorly water-soluble drugs. To facilitate oral administration, ASDs are …
and bioavailability of poorly water-soluble drugs. To facilitate oral administration, ASDs are …
Exploring the role of surfactants in enhancing drug release from amorphous solid dispersions at higher drug loadings
To reduce the dosage size of amorphous solid dispersion (ASD)-based formulations, it is of
interest to devise formulation strategies that allow increased drug loading (DL) without …
interest to devise formulation strategies that allow increased drug loading (DL) without …
Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization, and glass …
Drug loading is an important parameter known to impact the release rate of a poorly soluble
drug from an amorphous solid dispersion (ASD). Recent studies have shown that small …
drug from an amorphous solid dispersion (ASD). Recent studies have shown that small …
Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers
The objective of the current study is to mechanistically differentiate the dissolution and
supersaturation behaviors of amorphous drugs from amorphous solid dispersions (ASDs) …
supersaturation behaviors of amorphous drugs from amorphous solid dispersions (ASDs) …
Role of surfactants in improving release from higher drug loading amorphous solid dispersions
Amorphous solid dispersion formulations (ASD) are increasingly being used as a
formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations …
formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations …
Interplay of drug–polymer interactions and release performance for hpmcas-based amorphous solid dispersions
The interplay between drug and polymer chemistry and its impact on drug release from an
amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release …
amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release …