Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies.
A better understanding of the complex modifications of the immune system of septic patients …

Sepsis is one of the major causes of death in the hospital worldwide. The pathology of
sepsis is tightly associated with dysregulation of innate immune responses. The contribution …

Natural killer (NK) cells are large granular lymphocytes largely recognized for their
importance in tumour surveillance and the host response to viral infections. However, as the …

Sepsis is a devastating health condition originating due to the dysregulated immune
response in response to the severe systemic infection. The innate immune system serves as …

Rationale Natural killer cells, as a major source of interferon-γ, contribute to the amplification
of the inflammatory response as well as to mortality during severe sepsis in animal models …

Recently, several studies about the role of natural killer (NK) cells in sepsis have been
highlighted. In an earlier study, we characterized the abnormalities of circulating …

Most information about the immune status of NK cells during sepsis has been obtained from
animal models, athough data from clinical septic patients is limited. In this study, we aimed to …

Bacterial sepsis and septic shock are complex inflammatory disorders associated with a
systemic inflammatory response syndrome. In the most severe cases of infection, an …

Evidence suggests that NK and NKT cells contribute to inflammation and mortality during
septic shock caused by cecal ligation and puncture (CLP). However, the specific …

Although much information is available for the function of circulating monocytes when signs
of sepsis are apparent, little is known for natural killer (NK) cells. NK cells were isolated from …