Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to
memory loss and cognitive impairment over time. It is characterized by protein misfolding as …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling
pathways, collectively termed the Unfolded Protein Response (UPR). UPR signaling …

The endoplasmic reticulum (ER) performs the synthesis, posttranslational modification, and
proper folding of proteins. A variety of conditions can be ER stress, causing the …

Perturbed neuronal proteostasis is a salient feature shared by both aging and protein
misfolding disorders. The proteostasis network controls the health of the proteome by …

The unfolded protein response (UPR) is an integrated, adaptive biochemical process that is
inextricably linked with cell homeostasis and paramount to maintenance of normal …

Protein-folding occurs in several intracellular locations including the endoplasmic reticulum
and mitochondria. In normal conditions there is a balance between the levels of unfolded …

Cellular stresses that disrupt the processing of proteins slated for the secretory pathway
induce the unfolded protein response (UPR), a regulatory network involving both …

The unfolded protein response (UPR) is a homeostatic signaling pathway triggered by
protein misfolding in the endoplasmic reticulum (ER). Beyond its protective role, it plays …

Abnormally high levels of misfolded proteins in the endoplasmic reticulum (ER) lumen result
in a stress state that contributes to the progression of several pathological conditions …