Thymoquinone mitigate ischemia-reperfusion-induced liver injury in rats: a pivotal role of nitric oxide signaling pathway

M Abd-Elbaset, ESA Arafa, GA El Sherbiny… - Naunyn-Schmiedeberg's …, 2017 - Springer
Oxidative and nitrosative stress-induced endothelial cell damage play an essential role in
the pathogenesis of hepatic ischemia-reperfusion (IR) injury. IR is associated with reduced …

[HTML][HTML] Quercetin modulates iNOS, eNOS and NOSTRIN expressions and attenuates oxidative stress in warm hepatic ischemia-reperfusion injury in rats

M Abd-Elbaset, ESA Arafa, GA El Sherbiny… - Beni-Suef University …, 2015 - Elsevier
The pathogenesis of hepatic ischemia/reperfusion (I/R) is mediated through the generation
of oxidative and nitrosative stress-induced cell injury. Hence, the present study was …

Protective role of thymoquinone in sepsis‑induced liver injury in BALB/c mice

F Wang, X Lei, Y Zhao, Q Yu, Q Li… - Experimental and …, 2019 - spandidos-publications.com
Sepsis increases the risk of developing liver injury. Previous studies have demonstrated that
thymoquinone (TQ) exhibits hepatoprotective properties in vivo as well as in vitro. The …

Thymoquinone prevents endoplasmic reticulum stress and mitochondria-induced apoptosis in a rat model of partial hepatic warm ischemia reperfusion

A Bouhlel, IB Mosbah, NH Abdallah, C Ribault… - Biomedicine & …, 2017 - Elsevier
This study was undertaken to evaluate the protective effect of thymoquinone (TQ), the
bioactive compound of Nigella sativa seeds, against warm ischemia-reperfusion (I/R) injury …

[PDF][PDF] Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor

HI Lin, D Wang, F Leu, C Chen, HI Chen - Chinese journal of physiology, 2004 - cps.org.tw
The aim of this study was to investigate the role of nitric oxide (NO) in hepatic
ischemiareperfusion (I/R) injury in rats. Immunohistochemistry was used to examine the …

The protective role of two oxindole derivatives is mediated by modulating NLRP3/caspase-1 and PI3K/AKT pathways in a preclinical animal model of hepatic ischemia …

N Eldafashi, S Waaz, TFS Ali, MYW Zaki, MH Nazmy… - Life Sciences, 2024 - Elsevier
Aim Hepatic ischemia reperfusion injury (HIRI) is a leading cause of mortality post liver
transplantation, hypovolemic shock and trauma. In this study, we tested, on molecular bases …

Thymoquinone protects rat liver after partial hepatectomy under ischaemia/reperfusion through oxidative stress and endoplasmic reticulum stress prevention

A Bouhlel, M Bejaoui, I Ben Mosbah… - Clinical and …, 2018 - Wiley Online Library
Ischaemia reperfusion (I/R) is associated with liver injury and impaired regeneration during
partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone …

[PDF][PDF] Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury

RM Abd El-Ghany, NM Sharaf, LA Kassem… - Drug Discov …, 2009 - academia.edu
Thymoquinone (TQ) has been reported as a potent inducer of apoptosis in cancer cells.
However, the role of TQ as an apoptotic or antiapoptotic has not been established yet in …

Therapeutic effects of thymoquinone in doxorubicin‐induced hepatotoxicity via oxidative stress, inflammation and apoptosis

AT Akin, E Öztürk, E Kaymak… - Anatomia, histologia …, 2021 - Wiley Online Library
Cancer is a lethal disease that is characterized by uncontrolled cell division and
proliferation, and it results in death in many organisms. Doxorubicin (DOX) is a therapeutic …

Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways

Z Xu, Y Wang - Molecular medicine reports, 2014 - spandidos-publications.com
Hepatic ischemia reperfusion (HI/R) injury may occur during liver transplantation and
remains a serious concern in clinical practice. Huperzine A (HupA), an alkaloid isolated from …