Inflammasomes are multimolecular complexes with potent inflammatory activity. As such,
their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this …

The innate immune system represents the host's first-line defense against pathogens, dead
cells or environmental factors. One of the most important inflammatory pathways is …

Inflammasomes are multiprotein complexes nucleating around an NLR (Nucleotide-binding
domain and Leucine-rich Repeat containing protein), which regulate the secretion of the pro …

The innate immune system relies on its capability to detect invading microbes, tissue
damage, or stress via evolutionarily conserved receptors. The nucleotide-binding domain …

Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …

Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …

Inflammasomes are key regulators of the host response against microbial pathogens, in
addition to limiting aberrant responses to sterile insults, as mediated by environmental …

The importance of innate immunity lies not only in directly confronting pathogenic and non-
pathogenic insults but also in instructing the development of an efficient adaptive immune …