Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the
neurodegenerative disease amyotrophic lateral sclerosis (ALS). Two recent studies …

Dominant mutations in two DNA/RNA binding proteins, TDP-43 and FUS/TLS, are causes of
inherited Amyotrophic Lateral Sclerosis (ALS). TDP-43 and FUS/TLS have striking structural …

Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per
100,000 people worldwide, encompasses at least five distinct pathological subtypes …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of …

Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to
familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 …

TDP-43 and FUS are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar
degeneration (FTLD), and loss of function of either protein contributes to these …

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that
preferentially targets motor neurons. It was recently found that dominant mutations in two …

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor
neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are clinically distinct
fatal neurodegenerative disorders. Increasing molecular evidence indicates that both …

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …