The mammalian main olfactory epithelium (MOE) recognizes and transduces olfactory cues
through a G protein-coupled, cAMP-dependent signaling cascade. Additional chemosensory …

The mammalian retina contains at least two guanylyl cyclases (GC1 and GC2) and two
guanylyl cyclase-activating proteins (GCAP1 and GCAP2). Here we present evidence of the …

The guanylate cyclase-activating proteins (GCAPs), Ca2+-binding proteins of the calmodulin
gene superfamily, function as regulators of photoreceptor guanylate cyclases. In contrast to …

The membrane-bound guanylyl cyclase in vertebrate photoreceptor cells is one of the key
enzymes in visual transduction. It is highly sensitive to the free calcium concentration ([Ca …

Retinal guanylate cyclases 1 and 2 (GC1 and GC2) are responsible for synthesis of cyclic
GMP in rods and cones, but their individual contributions to phototransduction are unknown …

Guanylate cyclase, which catalyzes the formation of cGMP from GTP, exists in both the
soluble and particulate fractions of cells. At least two different cellular compartments for the …

Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates
many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an …

Receptor guanylyl cyclase C (GC-C) is the target for the gastrointestinal hormones, guanylin,
and uroguanylin as well as the bacterial heat-stable enterotoxins. The major site of …

Guanylyl cyclase-activating proteins (GCAP) are EF-hand Ca 2+-binding proteins that
activate photoreceptor guanylyl cyclase (RetGC) in the absence of Ca 2+ and inhibit RetGC …

Soluble guanylyl cyclase is a heterodimer consisting of an α and β subunit and stimulation
occurs upon binding of NO to a prosthetic group. Little is known about the localization of …