Genetic spectrum of left ventricular non-compaction in paediatric patients

T Vershinina, Y Fomicheva, A Muravyev, J Jorholt… - Cardiology, 2020 - karger.com
Introduction: Left ventricular non-compaction (LVNC) represents a genetically
heterogeneous cardiomyopathy which occurs in both children and adults. Its genetic …

[HTML][HTML] Spectrum of clinical features and genetic profile of left ventricular noncompaction cardiomyopathy in children

A Paszkowska, A Mirecka-Rola… - Cardiogenetics, 2021 - mdpi.com
Background: Left ventricular noncompaction (LVNC) is a genetically determined
cardiomyopathy that occurs following a disruption of endomyocardial morphogenesis. The …

Targeted panel sequencing in adult patients with left ventricular non‐compaction reveals a large genetic heterogeneity

P Richard, F Ader, M Roux, E Donal, JC Eicher… - Clinical …, 2019 - Wiley Online Library
Left ventricular non‐compaction (LVNC) is a cardiomyopathy that may be of genetic origin;
however, few data are available about the yield of mutation, the spectrum of genes and …

Genetic basis of left ventricular noncompaction

P Rojanasopondist, L Nesheiwat… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Left ventricular noncompaction (LVNC) is the third most common pediatric
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …

Multiple genetic variants in adolescent patients with left ventricular noncompaction cardiomyopathy

S Liu, Y Xie, H Zhang, Z Feng, J Huang, J Huang… - International Journal of …, 2020 - Elsevier
Background Left ventricular noncompaction cardiomyopathy (LVNC) is a primary
cardiomyopathy with an unclear aetiology. The clinical symptoms range from asymptomatic …

[HTML][HTML] Genetic architecture of left ventricular noncompaction in adults

SB Ross, ES Singer, E Driscoll, N Nowak… - Human genome …, 2020 - nature.com
The genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …

The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy

YM Hoedemaekers, K Caliskan, M Michels… - Circulation …, 2010 - Am Heart Assoc
Background—Left ventricular (LV) noncompaction (LVNC) is a distinct cardiomyopathy
featuring a thickened bilayered LV wall consisting of a thick endocardial layer with …

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy

F Sedaghat-Hamedani, J Haas, F Zhu… - European heart …, 2017 - academic.oup.com
Aims In this study, we aimed to clinically and genetically characterize LVNC patients and
investigate the prevalence of variants in known and novel LVNC disease genes. Introduction …

[HTML][HTML] Genetic profile of left ventricular noncompaction cardiomyopathy in children—a single reference center experience

D Piekutowska-Abramczuk, A Paszkowska, E Ciara… - Genes, 2022 - mdpi.com
Background: Left ventricular noncompaction cardiomyopathy (LVNC) is a rare cardiac
disorder characterised by the presence of a two-layer myocardium with prominent …

The genetic architecture of left ventricular non-compaction reveals both substantial overlap with other cardiomyopathies and a distinct aetiology in a subset of cases

F Mazzarotto, MH Hawley, M Beltrami, L Beekman… - medRxiv, 2020 - medrxiv.org
Background Left ventricular non-compaction (LVNC) is a condition characterised by
trabeculations in the myocardial wall and is the subject of considerable conjecture as to …