Investigating the causes of increased aerobic glycolysis in tumors (Warburg Effect) has gone
in and out of fashion many times since it was first described almost a century ago. The field …

Fermenting glucose in the presence of enough oxygen to support respiration, known as
aerobic glycolysis, is believed to maximize growth rate. We observed increasing aerobic …

The Warburg effect, the propensity of some cells to metabolize glucose to lactate in the
presence of oxygen (also known as aerobic glycolysis), has long been observed in cancer …

Background Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates
of glucose fermentation in the presence of normal oxygen concentrations, also known as the …

Most cancer cells rely on glycolysis to generate ATP, even when oxygen is available.
However, merely inhibiting the glycolysis is insufficient for the eradication of cancer cells …

In early studies on energy metabolism of tumor cells, it was proposed that the enhanced
glycolysis was induced by a decreased oxidative phosphorylation. Since then it has been …

The down-regulation of the catalytic subunit of the mitochondrial H+-ATP synthase (β-F1-
ATPase) is a hallmark of most human carcinomas. This characteristic of the cancer cell …

Tumour cells thrive in environments that would be hostile to their normal cell counterparts.
Survival depends on the selection of cell lines that harbour modifications of both, gene …

Abstract In 1927, Otto Warburg and coworkers reported the increased uptake of glucose and
production of lactate by tumors in vivo as compared with normal tissues. This phenomenon …

Even in the presence of an adequate oxygen supply, many tumors metabolize the majority of
the glucose they take up through glycolysis. It has been a long-held belief that this glycolytic …