Cancer cells increase glucose uptake and reject lactic acid even in the presence of oxygen
(Warburg effect). This metabolism reorients glucose towards the pentose phosphate …

Recent studies have suggested that cancer cells behave as metabolic parasites, by inducing
oxidative stress in adjacent normal fibroblasts. More specifically, oncogenic mutations in …

The idea that conversion of glucose to ATP is an attractive target for cancer therapy has
been supported in part by the observation that glucose deprivation induces apoptosis in …

The slow growth of cells in the inner core of solid tumors presents a form of multidrug
resistance to most of the standard chemotherapeutic agents, which target the outer more …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …

Emerging evidence indicates that cancer is primarily a metabolic disease involving
disturbances in energy production through respiration and fermentation. The genomic …

Emerging evidence indicates that impaired cellular energy metabolism is the defining
characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal …

For decades, tumor cells have been considered defective in mitochondrial respiration due to
their dominant glycolytic metabolism. However, a growing body of evidence is now …

A considerable amount of knowledge has been produced during the last five years on the
bioenergetics of cancer cells, leading to a better understanding of the regulation of energy …

Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a
phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in …