Cancer is the second most important cause of death and new therapy modalities continue to
be developed and evolved. Cancer cells' metabolism is far different from the normal, healthy …

Our laboratory has reported that glucose is essential for glycolytic enzyme induction and
proliferation of mitogen‐activated rat thymocytes (41). Here we show that: 1) Resting …

Initial studies of cancer metabolism in the early 1920s found that cancer cells were
phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake …

A key aberrant biological difference between tumor cells and normal differentiated cells is
altered metabolism, whereby cancer cells acquire a number of stable genetic and epigenetic …

Cancer is characterized by disturbed homeostasis of self-renewing cell populations, and
their ability to seed and grow in multiple microenvironments. This overarching cellular …

A long-standing question in cancer biology has been why oxygenated tumors ferment the
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …

Cancer metabolism has emerged as an important area of research in recent years.
Elucidation of the metabolic differences between cancer and normal cells and the …

For generation of energy, cancer cells utilize glycolysis more vigorously than oxidative
phosphorylation in mitochondria (Warburg effect). We examined the energy metabolism of …

Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is
thought that tumor regrowth originates from GSCs, thus rendering GSCs an attractive target …

It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even
in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor …