New approaches to acute pancreatitis: role of inflammatory mediators

JG Norman - Digestion, 1999 - karger.com
Regardless of whether the initiating event is alcohol, gallstones or some other less common
cause, acute pancreatitis progresses in a predictable manner eventually leading to failure of …

Pathophysiology of pancreatitis Role of cytokines and other mediators of inflammation

AK Saluja, ML Steer - Digestion, 1999 - karger.com
Acute pancreatitis is an inflammatory disease, which varies in severity from mild to severe.
Factors determining the severity of pancreatitis are not known. It is generally believed that …

Pathophysiological mechanisms of acute pancreatitis define inflammatory markers of clinical prognosis

GA Minkov, KS Halacheva, YP Yovtchev… - Pancreas, 2015 - journals.lww.com
Abstract Development of acute pancreatitis illustrates the need to understand the basic
mechanisms of disease progression to drive the exploration of therapeutic options …

[HTML][HTML] Inflammation and immunosuppression in severe acute pancreatitis

ML Kylänpää, H Repo… - World journal of …, 2010 - ncbi.nlm.nih.gov
Acute pancreatitis (AP) is a common disease, which usually exists in its mild form. However,
in a fifth of cases, the disease is severe, with local pancreatic complications or systemic …

Pathophysiology of acute experimental pancreatitis: lessons from genetically engineered animal models and new molecular approaches

C Schäfer, AB Tietz, B Göke - Digestion, 2005 - karger.com
The incidence of acute pancreatitis is growing and worldwide population-based studies
report a doubling or tripling since the 1970s. 25% of acute pancreatitis are severe and …

Practical guide to the management of acute pancreatitis

G Goodchild, M Chouhan, GJ Johnson - Frontline Gastroenterology, 2019 - fg.bmj.com
Acute pancreatitis (AP) is characterised by inflammation of the exocrine pancreas and is
associated with acinar cell injury and both a local and systemic inflammatory response. AP …

Acute pancreatitis: a multifaceted set of organelle and cellular interactions

A Habtezion, AS Gukovskaya, SJ Pandol - Gastroenterology, 2019 - Elsevier
Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

Apoptosis versus necrosis in acute pancreatitis

M Bhatia - … Journal of Physiology-Gastrointestinal and Liver …, 2004 - journals.physiology.org
Acute pancreatitis is a disease of variable severity in which some patients experience mild,
self-limited attacks, whereas others manifest a severe, highly morbid, and frequently lethal …

Early events in acute pancreatitis

ML Steer - Best Practice & Research Clinical Gastroenterology, 1999 - Elsevier
Studies using experimental models indicate that the earliest changes in acute pancreatitis
involve intra-acinar cell events including the co-localization of lysosomal hydrolases with …

Current management of acute pancreatitis

J Mayerle, V Hlouschek, MM Lerch - Nature Clinical Practice …, 2005 - nature.com
The incidence of acute pancreatitis varies considerably between regions and is estimated at
5–80 per 100,000 population. The mortality rate of acute edematous-interstitial pancreatitis …