[HTML][HTML] Acetaminophen-induced hepatotoxicity predominantly via inhibiting Nrf2 antioxidative pathway and activating TLR4-NF-κB-MAPK inflammatory response in …
XL Shen, YN Guo, MH Lu, KN Ding, SS Liang… - Ecotoxicology and …, 2023 - Elsevier
To explore the action time and molecular mechanism underlying the effect of
acetaminophen (APAP) on liver injury. APAP was used to establish drug-induced liver injury …
acetaminophen (APAP) on liver injury. APAP was used to establish drug-induced liver injury …
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis
Z Gao, H Zhan, W Zong, M Sun, L Linghu, G Wang… - Life Sciences, 2023 - Elsevier
Acetaminophen (APAP) overdose-induced hepatotoxicity is the most common cause of drug-
induced liver injury worldwide, which is significantly linked to oxidative stress and sterile …
induced liver injury worldwide, which is significantly linked to oxidative stress and sterile …
[HTML][HTML] Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis
DH El-Kashef, MH Sharawy - Environmental Science and Pollution …, 2023 - Springer
Acetaminophen (APAP) overdose can produce hepatotoxicity and consequently liver
damage. This study investigated the hepatoprotective impacts of nicorandil on hepatic …
damage. This study investigated the hepatoprotective impacts of nicorandil on hepatic …
Nicotinic acid against acetaminophen-induced hepatotoxicity via Sirt1/Nrf2 antioxidative pathway in mice
D Hu, L Zhang, R Jiang, C Liao, J Xu… - Journal of nutritional …, 2021 - jstage.jst.go.jp
Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …
The cross-talk of NLRP3 inflammasome activation and necroptotic hepatocyte death in acetaminophen-induced mice acute liver injury
L Li, S Shan, K Kang, C Zhang… - Human & …, 2021 - journals.sagepub.com
Overdose acetaminophen (APAP) can result in severe liver injury, which is responsible for
nearly half of drug-induced liver injury in western countries. Previous studies have found that …
nearly half of drug-induced liver injury in western countries. Previous studies have found that …
Role of caspase-8 and/or-9 as biomarkers that can distinguish the potential to cause toxic-and immune related-adverse event, for the progress of acetaminophen …
T Noda, R Kato, T Hattori, Y Furukawa, Y Ijiri, K Tanaka - Life Sciences, 2022 - Elsevier
Aims Acetaminophen (APAP) overdose can cause acute liver failure. Although it is well
known that APAP-induced liver injury (AILI) is caused by toxic mechanism, recently it is also …
known that APAP-induced liver injury (AILI) is caused by toxic mechanism, recently it is also …
Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration
Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …
[HTML][HTML] Characterization of acetaminophen-induced cytotoxicity in target tissues
C Guo, G Xie, M Su, X Wu, X Lu, K Wu… - American Journal of …, 2016 - ncbi.nlm.nih.gov
Acetaminophen (APAP), commonly used in clinical prescription, has time-and dose-
dependent side effects. Thus, further animal study warrants to be investigated to assess …
dependent side effects. Thus, further animal study warrants to be investigated to assess …
[HTML][HTML] Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling
YM He, XL Shen, YN Guo, SS Liang, KN Ding… - Ecotoxicology and …, 2022 - Elsevier
This study aimed to investigate the protective effect and potential mechanism of Yinhuang
oral liquid (YOL) against acetaminophen (APAP) induced liver injury in mice. C57BL/6 mice …
oral liquid (YOL) against acetaminophen (APAP) induced liver injury in mice. C57BL/6 mice …
[HTML][HTML] Maltol improves APAP-induced hepatotoxicity by inhibiting oxidative stress and inflammation response via NF-κB and PI3K/Akt signal pathways
Z Wang, W Hao, J Hu, X Mi, Y Han, S Ren, S Jiang… - Antioxidants, 2019 - mdpi.com
Maltol, a food-flavoring agent and Maillard reaction product formed during the processing of
red ginseng (Panax ginseng, CA Meyer), has been confirmed to exert a hepatoprotective …
red ginseng (Panax ginseng, CA Meyer), has been confirmed to exert a hepatoprotective …