A low dose of pure cannabidiol is sufficient to stimulate the cytotoxic function of cik cells without exerting the downstream mediators in pancreatic cancer cells

F Garofano, A Sharma, H Abken… - International Journal of …, 2022 - mdpi.com
Despite numerous studies conducted over the past decade, the exact role of the
cannabinoid system in cancer development remains unclear. Though research has focused …

High expression of cannabinoid receptor 2 on cytokine-induced killer cells and multiple myeloma cells

F Garofano, IGH Schmidt-Wolf - International Journal of Molecular …, 2020 - mdpi.com
Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC)
proliferation and is one of the most common hematological malignancies. The potential …

Cannabinoids inhibited pancreatic cancer via P-21 activated kinase 1 mediated pathway

Y Yang, N Huynh, C Dumesny, K Wang, H He… - International journal of …, 2020 - mdpi.com
The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((−)-trans-∆ 9-
tetrahydrocannabinol) have been reported in the case of pancreatic cancer (PC). The …

Cannabidiol treatment results in a common gene expression response across aggressive cancer cells from various origins

PY Desprez, R Murase, C Limbad… - Cannabis and …, 2021 - liebertpub.com
Background: We previously reported that cannabidiol (CBD), a cannabinoid with a low
toxicity profile, downregulated the expression of the prometastatic gene inhibitor of DNA …

Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells

HS Lee, G Tamia, HJ Song, D Amarakoon… - International …, 2022 - Elsevier
Colorectal cancer is the third leading cause of cancer incidence and mortality in the United
States. Cannabidiol (CBD), the second most abundant phytocannabinoid in Cannabis …

[HTML][HTML] Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism

S Fogli, P Nieri, A Chicca, B Adinolfi, V Mariotti… - FEBS letters, 2006 - Elsevier
Cannabinoids (CBs) are implicated in the control of cell survival in different types of tumors,
but little is known about the role of CB system in pancreatic cancer. Herein, we investigated …

Differential role of cannabinoids in the pathogenesis of skin cancer

N Glodde, M Jakobs, T Bald, T Tüting, E Gaffal - Life Sciences, 2015 - Elsevier
Abstract Aim Cannabinoids (CB) like∆ 9-tetrahydrocannabinol (THC) can induce cancer cell
apoptosis and inhibit angiogenesis. However, the use of cannabinoids for the treatment of …

Antitumor mechanism of cannabidiol hidden behind cancer hallmarks

C Yan, Y Li, H Liu, D Chen, J Wu - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Cannabinoids have been utilized for recreational and therapeutic purposes for over 4,000
years. As the primary ingredient in exogenous cannabinoids, Cannabidiol (CBD) has drawn …

[HTML][HTML] Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells

MW Ko, B Breznik, E Senjor, A Jewett - Advances in Cancer Biology …, 2022 - Elsevier
We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and
induces cell death of oral and pancreatic tumor cells, and the effect is much more …

Anti-proliferative and cytotoxic effect of cannabidiol on human cancer cell lines in presence of serum

A Sainz-Cort, C Müller-Sánchez, E Espel - BMC research notes, 2020 - Springer
Objective Cannabinoids are able to reduce tumor growth in xenograft models, but their
therapeutic potential as anti-cancer drugs in humans is unclear yet. In vitro studies of the …