Purpose: Neural tube defects (NTDs), including spina bifida and anencephaly, are common
congenital malformations that occur when the neural tube fails to achieve proper closure …

BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …

The vertebrate central nervous system is a hollow structure that develops first as a flat sheet
of cells and subsequently rolls into a tube during embryogenesis. Failure of this rolling …

We present evidence for multisite NT closure in humans with representative examples of
types of NTDs that would be expected if NT closure in humans is similar to experimental …

Editorial through spinal defect and histopathological findings.[2] Majority of NTDs are
isolated/non-syndromic and are not associated with other congenital malformations …

Neural tube defects are dreadful congenital deformities of the nervous system that occur
owing to failure of normal neural tube closure. Genetic and non-genetic factors contribute to …

Neural tube defects (NTDs) are common congenital malformations that occur when the
embryonic neural tube fails to close properly during early development. Although …

Four separate initiation sites for neural tube (NT) fusion have been demonstrated recently in
mice and other experimental animals. We evaluated the question of whether the mult‐site …

Neural tube defects (NTDs) are severe congenital malformations affecting 1 in every 1000
pregnancies.'Open'NTDs result from failure of primary neurulation as seen in anencephaly …

The human neural tube defects (NTD), anencephaly, spina bifida and craniorachischisis,
originate from a failure of the embryonic neural tube to close. Human NTD are relatively …