The bZIP transcription factor Nrf2 has emerged as a pivotal regulator of intracellular redox
homeostasis by controlling the expression of many endogenous antioxidants and phase II …

To maintain intracellular redox homeostasis, genes encoding many antioxidants and
detoxification enzymes are transcriptionally upregulated upon deleterious oxidative stress …

The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions,
Keap1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin …

Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated
transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes …

Keap1 is an inhibitor of Nrf2 involved in Nrf2-dependent antioxidant response. However, the
mechanisms on how Keap1 regulates Nrf2-ARE signaling pathway remains to be …

Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to
oxidative stress. Previous studies suggested this negative regulation is a consequence of …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

Nrf2 is the key transcription factor regulating the antioxidant response. Nrf2 signaling is
repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently …

Nrf2 (NF-E2-related factor 2) is a central transcription factor involved in the transcriptional
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant …

Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …