Summary Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs).
Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian …

Clathrin-mediated endocytosis occurs via the assembly of clathrin-coated pits (CCPs) that
invaginate and pinch off to form clathrin-coated vesicles (CCVs). It is well known that adaptor …

Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells
control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 …

Clathrin-coated pit (CCP) formation occurs as a result of the targeting and assembly of
cytosolic coat proteins, mainly the plasma membrane clathrin-associated protein complex …

Recent data have shown that Eps15, a newly identified component of clathrin-coated pits
constitutively associated with the AP-2 complex, is required for receptor-mediated …

Defective endocytosis and vesicular trafficking of signaling receptors has recently emerged
as a multifaceted hallmark of malignant cells. Clathrin-coated pits (CCPs) display highly …

The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and
when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which …

Clathrin-mediated endocytosis, an essential process for plasma membrane homeostasis
and cell signaling, is characterized by stunning heterogeneity in the size and lifetime of …

Clathrin light chains (CLCs) control selective uptake of a range of G protein–coupled
receptors (GPCRs), although the mechanism by which this occurs has remained elusive …

Clathrin-mediated endocytosis (CME) is the major mechanism for internalization in
mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin …