Background SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is
controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might …

Pulmonary metastasis is the leading cause of mortality in patients with osteosarcoma;
however, the underlying mechanism remains unclear. The NAD+-dependent deacetylase …

SIRT6 is an important histone modifying protein that regulates DNA repair, telomere
maintenance, energy metabolism, and target gene expression. Recently SIRT6 has been …

Background Optimal therapeutic strategies for hepatocellular carcinoma (HCC) patients are
still challenging due to the high recurrence rate after surgical resection and chemotherapy …

It is still a controversy whether the role of Sirtuin 7 (SIRT7) is an oncogene or a tumor
suppressor gene in cancer as SIRT7 may have different functions in different types of …

SIRT6, is a member of the NAD‑dependent sirtuin family of enzymes, and has been reported
as a novel tumor suppressor gene or oncogene, dependent on the type of cancer. However …

Osteosarcomas (OS) are highly metastatic and usually lead to poor outcomes. Epithelial-
mesenchymal transition (EMT) is reported to be a critical event in metastasis. SIRT2 exerts …

In this study, we report the identification of a novel role of SIRT6 in both epirubicin and
paclitaxel resistance in breast cancer. We found that SIRT6 protein levels are elevated in …

Dysregulation of sirtuin 6 (SIRT6) is actively involved in tumor progression. High levels of
SIRT6 have been associated with hepatocellular carcinoma and non‐small cell lung cancer …

Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …