Cardiac hypertrophy occurs in pathological conditions associated with chronic increases in
hemodynamic load. Although hypertrophy can initially be viewed as a salutary response …

Nitric oxide (NO) is generated by NO synthases (NOSs) that convert L-arginine to L-citrulline
in the presence of molecular oxygen, nicotinamide-adenine dinucleotide phosphate …

Endogenous myocardial nitric oxide (NO) may modulate the transition from adaptive to
maladaptive remodeling leading to heart failure. In rodent models of pressure overload or …

Endogenous myocardial nitric oxide (NO) may modulate the transition from adaptive to
maladaptive hypertrophy leading to heart failure. This review summarizes the information on …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Nitric oxide (NO) plays a crucial role in many aspects of the pathophysiology of heart failure.
NO is a double-edged sword; NO inhibits ischemia/reperfusion (I/R) injury, represses …

Identification of all three nitric oxide (NO) synthase (NOS) isoforms in cardiac myocytes and
the recognition of the importance of their subcellular localization have greatly advanced the …

Nitric oxide (NO) is an important modulator of cardiac performance and left ventricular (LV)
remodeling after myocardial infarction (MI). We tested the effect of cardiomyocyte-restricted …

The three isoforms of nitric oxide synthase (NOS), spatially confined in specific intracellular
compartments in cardiac cells, have distinct roles in the regulation of contractility in …

The mammalian heart expresses all three isoforms of nitric oxide synthases (NOS) in diverse
cell types of the myocardium. Despite their apparent promiscuity, the NOS isoforms support …