Multiple lines of evidence suggest that aberrant induction and upregulation of the
prostaglandin cascade play a significant role in colon and mammary carcinogenesis, and …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers has spurred novel approaches to cancer …

Several lines of evidence suggest that the cyclooxygenase enzymes (specifically COX-2)
might be an important molecular target for the intervention of cancer at both early and late …

NSAIDs (non-steroidal anti-inflammatory drugs) prevent colon and other cancers. The fact
that NSAIDs inhibit the eicosanoid pathway prompted mechanistic drug-developmental work …

The decisive epidemiological observation that non-steroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers as well has spurred novel approaches to …

The rate-limiting step in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

Prior to the discovery of cyclooxygenase-2 (COX-2), a beneficial association was shown
between chronic usage of non steroidal anti-inflammatory drugs (NSAIDs), that …

Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …