Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol
M Yang, J Miao, J Rizak, R Zhai… - Journal of …, 2014 - content.iospress.com
A recently established link between formaldehyde, a methanol metabolite, and Alzheimer's
disease (AD) pathology has provided a new impetus to investigate the chronic effects of …
disease (AD) pathology has provided a new impetus to investigate the chronic effects of …
Alzheimer's disease and methanol toxicity (part 1): chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice
M Yang, J Lu, J Miao, J Rizak, J Yang… - Journal of …, 2014 - content.iospress.com
Although methanol toxicity is well known for acute neurological sequelae leading to
blindness or death, there is a new impetus to investigate the chronic effects of methanol …
blindness or death, there is a new impetus to investigate the chronic effects of methanol …
Alzheimer's disease-like pathologies and cognitive impairments induced by formaldehyde in non-human primates
R Zhai, J Rizak, NA Zheng, X He, Z Li… - Current Alzheimer …, 2018 - ingentaconnect.com
Background: Formaldehyde (FA) has been implicated in Alzheimer's disease (AD) pathology
as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Aβ) …
as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Aβ) …
Low concentrations of ethanol protect against synaptotoxicity induced by Aβ in hippocampal neurons
G Muñoz, JC Urrutia, CF Burgos, V Silva, F Aguilar… - Neurobiology of …, 2015 - Elsevier
Epidemiological studies have reported a reduction in the prevalence of Alzheimer's disease
in individuals that ingest low amounts of alcohol. Also, it has been found that moderate …
in individuals that ingest low amounts of alcohol. Also, it has been found that moderate …
Evidence for conversion of methanol to formaldehyde in nonhuman primate brain
R Zhai, N Zheng, J Rizak, X Hu - Analytical Cellular Pathology, 2016 - Wiley Online Library
Many studies have reported that methanol toxicity to primates is mainly associated with its
metabolites, formaldehyde (FA) and formic acid. While methanol metabolism and toxicology …
metabolites, formaldehyde (FA) and formic acid. While methanol metabolism and toxicology …
[HTML][HTML] Alcohol as a modifiable risk factor for Alzheimer's disease—Evidence from experimental studies
DV Chandrashekar, RA Steinberg, D Han… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive impairment and memory loss. Epidemiological evidence suggests that heavy …
cognitive impairment and memory loss. Epidemiological evidence suggests that heavy …
[HTML][HTML] Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice
SM Day, SC Gironda, CW Clarke, JA Snipes… - Neurobiology of …, 2023 - Elsevier
Epidemiological studies identified alcohol use disorder (AUD) as a risk factor for Alzheimer's
disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology …
disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology …
[HTML][HTML] Chronic ethanol causes persistent increases in Alzheimer's tau pathology in female 3xTg-AD mice: a potential role for lysosomal impairment
AE Tucker, CM Alicea Pauneto, AM Barnett… - Frontiers in Behavioral …, 2022 - frontiersin.org
Epidemiological studies have found that heavy alcohol use is associated with increased risk
for Alzheimer's disease (AD), with frequent drinking earlier in adulthood increasing risk. The …
for Alzheimer's disease (AD), with frequent drinking earlier in adulthood increasing risk. The …
Ethanol withdrawal is required to produce persisting N-methyl-D-aspartate receptor-dependent hippocampal cytotoxicity during chronic intermittent ethanol exposure
AR Reynolds, JN Berry, L Sharrett-Field… - Alcohol, 2015 - Elsevier
Chronic intermittent ethanol consumption is associated with neurodegeneration and
cognitive deficits in preclinical laboratory animals and in the clinical population. While …
cognitive deficits in preclinical laboratory animals and in the clinical population. While …
Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate …
NF Tajuddin, MM Przybycien-Szymanska, TR Pak… - Alcohol, 2013 - Elsevier
Collaborating on studies of subchronic daily intoxication in juvenile and adult rats, we
examined whether the repetitive ethanol treatments at these two life stages altered levels of …
examined whether the repetitive ethanol treatments at these two life stages altered levels of …