Dynamic palmitoylation is an important post-translational modification regulating protein
localization, trafficking, and signaling activities. The Asp-His-His-Cys (DHHC) domain …

Protein palmitoyltransferases (PATs) represent an exciting new target for anticancer drug
design due to their pivotal roles in the subcellular localization of a number of oncogenes. We …

Although protein S-palmitoylation was first characterized> 30 years ago, and is implicated in
the function, trafficking, and localization of many proteins, little is known about the regulation …

Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target
proteins. It regulates multiple aspects of protein function, including the localization to …

S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular
proteins. Palmitoylation can affect proteins in many different ways, including regulating …

Protein S-palmitoylation is a reversible post-translational modification that regulates many
key biological processes, although the full extent and functions of protein S-palmitoylation …

Post-translational S-palmitoylation directs the trafficking and membrane localization of
hundreds of cellular proteins, often involving a coordinated palmitoylation cycle that requires …

INTRODUCTION Hundreds of cellular proteins are modified by posttranslational S-acylation
of cysteines, commonly known as protein palmitoylation. Unlike other lipid attachments …

Protein S-palmitoylation is a covalent and reversible lipid modification that specifically
targets cysteine residues within many eukaryotic proteins. In mammalian cells, the …

DHHC-type protein acyltransferases may regulate the localization, stability, and/or activity of
their substrates. In this study, we show that the protein palmitoyltransferase DHHC3 is …