Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
J Cao, JL Li, D Li, JF Tobin… - Proceedings of the …, 2006 - National Acad Sciences
Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …
GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis [S]
D Shan, J Li, L Wu, D Li, J Hurov, JF Tobin… - Journal of lipid …, 2010 - ASBMB
Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report …
novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report …
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase
YQ Chen, MS Kuo, S Li, HH Bui, DA Peake… - Journal of Biological …, 2008 - ASBMB
AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family
that appears to be important in triglyceride biosynthesis in several tissues, but the precise …
that appears to be important in triglyceride biosynthesis in several tissues, but the precise …
Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria
TM Lewin, NMJ Schwerbrock, DP Lee… - Journal of Biological …, 2004 - ASBMB
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of
glycerolipid synthesis. Two distinct GPAT isoenzymes had been identified in mammalian …
glycerolipid synthesis. Two distinct GPAT isoenzymes had been identified in mammalian …
Liver‐directed overexpression of mitochondrial glycerol‐3‐phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty …
D Lindén, L William‐Olsson, A Ahnmark… - The FASEB …, 2006 - Wiley Online Library
Glycerol‐3‐phosphate acyltransferase (GPAT) catalyzes the first committed step in
triacylglycerol (TAG) and phospholipid biosynthesis. GPAT activity has been identified in …
triacylglycerol (TAG) and phospholipid biosynthesis. GPAT activity has been identified in …
Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)
S Wang, DP Lee, N Gong, NMJ Schwerbrock… - Archives of biochemistry …, 2007 - Elsevier
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step in
glycerolipid synthesis. Several mammalian GPAT activities have been recognized, including …
glycerolipid synthesis. Several mammalian GPAT activities have been recognized, including …
Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol
RA Igal, S Wang, M Gonzalez-Baró… - Journal of Biological …, 2001 - ASBMB
The mitochondrial isoform of glycerol-3-phosphate acyltransferase (GPAT), the first step in
glycerolipid synthesis, is up-regulated by insulin and by high carbohydrate feeding via …
glycerolipid synthesis, is up-regulated by insulin and by high carbohydrate feeding via …
Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation
AA Wendel, DE Cooper, OR Ilkayeva, DM Muoio… - Journal of Biological …, 2013 - ASBMB
Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, each encoded by a separate
gene, catalyze the initial step in glycerolipid synthesis; in liver, the major isoforms are …
gene, catalyze the initial step in glycerolipid synthesis; in liver, the major isoforms are …
Glycerophosphate/acylglycerophosphate acyltransferases
A Yamashita, Y Hayashi, N Matsumoto… - Biology, 2014 - mdpi.com
Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …
Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity
J Cao, S Perez, B Goodwin, Q Lin… - American Journal …, 2014 - journals.physiology.org
Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of
glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is …
glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is …