Glycerophospholipids and triglycerides are synthesized de novo by cells through an
evolutionary conserved process involving serial acylations of phosphorylated glycerol …

Mutations in the 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) gene have been
identified in individuals affected with congenital generalized lipodystrophy (CGL). AGPAT2 …

Glycerol-3-phosphate acyltransferase-1 (GPAT1), which is located on the outer
mitochondrial membrane comprises up to 30% of total GPAT activity in the heart. It is one of …

Because excess triacylglycerol (TAG) in nonadipose tissues is closely associated with the
development of insulin resistance, interest has increased in the metabolism of long-chain …

Rat mitochondrial glycerol-3-phosphate acyltransferase (GPAT) cDNA was cloned and
characterized. We identified a cDNA containing an open reading frame of 828 amino acids …

AGPAT (1-acyl-sn-glycerol 3-phosphate acyltransferase) exists in at least five isoforms in
humans, termed as AGPAT1, AGPAT2, AGPAT3, AGPAT4 and AGPAT5. Although they …

Acyl-CoA: monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of
diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and …

Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have
important roles in metabolic homeostasis. The molecular identification of genes encoding …

Acyl-CoA: monoacylglycerol transferase (MGAT) plays a predominant role in dietary fat
absorption in the small intestine, where it catalyzes the first step of triacylglycerol resynthesis …

Acyl CoA: monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of
diacylglycerol, a precursor of triacylglycerol. In the intestine, MGAT plays a major role in the …