Linear regression modeling on a database of HIV-1 genotypes and phenotypes was applied
to predict the HIV-1 resistance phenotype from the viral genotype. In this approach, the …

Understanding the genetic basis of HIV-1 drug resistance is essential to developing new
antiretroviral drugs and optimizing the use of existing drugs. This understanding, however, is …

Drug resistance testing has been shown to be beneficial for clinical management of HIV type
1 infected patients. Whereas phenotypic assays directly measure drug resistance, the …

Objectives The development of a genotypic drug resistance interpretation algorithm, and the
evaluation of its power to predict therapy outcome. Design A rule-based algorithm was …

This paper establishes a framework for understanding the complex relationships between
HIV‐1 genotypic markers of resistance to antiretroviral drugs and clinical measures of …

Drug resistance is a major obstacle to the successful treatment of HIV-1 infection. Genotypic
assays are used widely to provide indirect evidence of drug resistance, but the performance …

Objectives: To compare three methods for using HIV-1 genotype to predict antiretroviral drug
susceptibility. Methods: We applied three genotypic interpretation algorithms to 478 reverse …

Concordance between the conventional HIV‐1 phenotypic drug resistance assay,
PhenoSense™(PS), and virco® TYPE HIV‐1 (vT), a drug resistance assay based on …

Therapeutic success of anti-HIV therapies is limited by the development of drug resistant
viruses. These genetic variants display complex mutational patterns in their pol gene, which …

Background HIV/AIDS is a serious threat to public health. The emergence of drug resistance
mutations diminishes the effectiveness of drug therapy for HIV/AIDS. Developing a …