The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …

The massive surge in genome sequencing projects has opened our eyes to the overlooked
biosynthetic potential and metabolic diversity of microorganisms. While traditional …

Genomics-based methods are now commonplace in natural products research. A phylogeny-
guided mining approach provides a means to quickly screen a large number of microbial …

Microbial genome mining is a rapidly developing approach to discover new and novel
secondary metabolites for drug discovery. Many advances have been made in the past …

New drugs from silent gene clusters: Analysis of genome sequence data has identified
numerous “cryptic” gene clusters encoding novel natural product biosynthetic assembly …

Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

The quest for the discovery of novel natural products has entered a new chapter with the
enormous wealth of genetic data that is now available. This information has been exploited …

Microbial genome mining for drug discovery and development has been accelerating in
recent years, driven by technical advancements in genome sequencing, bioinformatics …

Natural products (NPs) are a major source of compounds for medical, agricultural, and
biotechnological industries. Many of these compounds are of microbial origin, and, in …

Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …