Cellular models of memory formation have focused on the need for protein synthesis.
Recently, evidence has emerged that protein degradation mediated by the ubiquitin …

Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …

The ubiquitin-proteasome system (UPS) is a ubiquitous, major pathway of protein
degradation that is involved in most cellular processes by regulating the abundance of …

Quite intuitive is the notion that memory formation and consolidation is orchestrated by
protein synthesis because of the synaptic plasticity necessary for those processes …

The ubiquitin-proteasome pathway (UPP) of protein degradation has many roles in synaptic
plasticity that underlies memory. Work on both invertebrate and vertebrate model systems …

It is clear that de novo protein synthesis has an important function in synaptic transmission
and plasticity. A substantial amount of work has shown that mRNA translation in the …

The proteasome is a structural complex of many proteins that degrades substrates marked
by covalent linkage to ubiquitin. Many years of research has shown a role for ubiquitin …

Synaptic Plasticity: Importance of Proteasome-Mediated Protein Turnover: Current Biology
Skip to Main Content Advertisement Current Biology This journal offers authors two options (open …

Proteolysis by the ubiquitin-proteasome pathway (UPP) has emerged as a new molecular
mechanism that controls wide-ranging functions in the nervous system, including fine-tuning …

Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …