Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies
In searchof the potenttherapeutic agent as an α-glucosidase inhibitor, we have synthesized
twenty-five analogs (1–25) of quinoline-based Schiff bases as an inhibitoragainst α …
twenty-five analogs (1–25) of quinoline-based Schiff bases as an inhibitoragainst α …
Design, Synthesis, In‐Vivo Anti‐Diabetic Activity, In‐Vitro α‐Glucosidase Inhibitory Activity and Molecular Docking Studies of Some Quinazolinone Derivatives
A Ibrahim, HM Sakr, RR Ayyad, MM Khalifa - ChemistrySelect, 2022 - Wiley Online Library
A new series of quinazolinone bearing acetamide derivatives were designed and
synthesized. The designed compounds were tested for their in vivo anti‐hyperglycemic …
synthesized. The designed compounds were tested for their in vivo anti‐hyperglycemic …
Design, synthesis, and biological evaluation of quinazoline derivatives as α-glucosidase inhibitors
V Gurram, R Garlapati, C Thulluri, N Madala… - Medicinal Chemistry …, 2015 - Springer
To develop a lead anti-diabetic compound, a series of 21 novel quinazoline derivatives have
been synthesized and screened against α-glucosidase. The binding mode of the …
been synthesized and screened against α-glucosidase. The binding mode of the …
[HTML][HTML] Design, synthesis, and in silico studies of quinoline-based-benzo [d] imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
M Noori, A Davoodi, A Iraji, N Dastyafteh, M Khalili… - Scientific Reports, 2022 - nature.com
In this study, 18 novel quinoline-based-benzo [d] imidazole derivatives were synthesized
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
Exploring thiazole-based Schiff base analogs as potent α-glucosidase and α-amylase inhibitor: their synthesis and in-silico study
In search of potent antidiabetic agents here in this study a new series of thiazole-based
Schiff base analogs (1–20) have been synthesized, characterized by 1 HNMR, 13 CNMR …
Schiff base analogs (1–20) have been synthesized, characterized by 1 HNMR, 13 CNMR …
Quinazolinone derivatives: Synthesis and comparison of inhibitory mechanisms on α-glucosidase
M Wei, WM Chai, R Wang, Q Yang, Z Deng… - Bioorganic & Medicinal …, 2017 - Elsevier
In this study, eight quinazolinone derivatives were designed and synthesized. Their
inhibitory activities on α-glucosidase were assessed in vitro. Two compounds: 2-(4 …
inhibitory activities on α-glucosidase were assessed in vitro. Two compounds: 2-(4 …
[HTML][HTML] Aryl-oxadiazole Schiff bases: Synthesis, α-glucosidase in vitro inhibitory activity and their in silico studies
Abstract α-Glucosidase enzyme is a therapeutic target for diabetes mellitus and its inhibitors
play a vital role in the treatment of this disease. A new series of aryl-oxadiazole Schiff bases …
play a vital role in the treatment of this disease. A new series of aryl-oxadiazole Schiff bases …
Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study
In this study, we have investigated a series of indole-based compounds for their inhibitory
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
Novel Bis-Schiff's base derivatives of 4-nitroacetophenone as potent α-glucosidase agents: Design, synthesis and in silico approach
Bis-Schiff's base derivatives of 4-nitroacetophenone (1–18) were synthesized in good yields
by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with …
by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with …
Design and synthesis of new benzylidene-quinazolinone hybrids as potential anti-diabetic agents: In vitro α-glucosidase inhibition, and docking studies
MM Khalifa, HM Sakr, A Ibrahim, AM Mansour… - Journal of Molecular …, 2022 - Elsevier
A novel series of benzylidene-quinazolinone hybrids 8 a, b and 10 an were designed,
synthesized, and evaluated for their in vitro α-glucosidase inhibitory effect aiming to discover …
synthesized, and evaluated for their in vitro α-glucosidase inhibitory effect aiming to discover …